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Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease

Gluten are proline- and glutamine-rich proteins present in wheat, barley, and rye and contain the immunogenic sequences that drive celiac disease (CD). Rothia mucilaginosa, an oral microbial colonizer, can cleave these gluten epitopes. The aim was to isolate and identify the enzymes and evaluate the...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Gastrointest Liver Physiol
Huvudupphovsmän: Wei, Guoxian, Tian, Na, Siezen, Roland, Schuppan, Detlef, Helmerhorst, Eva J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076000/
https://ncbi.nlm.nih.gov/pubmed/27469368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00185.2016
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