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Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease

Gluten are proline- and glutamine-rich proteins present in wheat, barley, and rye and contain the immunogenic sequences that drive celiac disease (CD). Rothia mucilaginosa, an oral microbial colonizer, can cleave these gluten epitopes. The aim was to isolate and identify the enzymes and evaluate the...

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Опубликовано в: :Am J Physiol Gastrointest Liver Physiol
Главные авторы: Wei, Guoxian, Tian, Na, Siezen, Roland, Schuppan, Detlef, Helmerhorst, Eva J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076000/
https://ncbi.nlm.nih.gov/pubmed/27469368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00185.2016
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