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Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural microbial colonizer of the oral cavity. The challe...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6522598/ https://ncbi.nlm.nih.gov/pubmed/31097786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43837-9 |
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