Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease

OBJECTIVES: Immunogenic gluten proteins implicated in celiac disease (CD) largely resist degradation by human digestive enzymes. Here we pursued the isolation of gluten-degrading organisms from human feces, aiming at bacteria that would digest gluten under acidic conditions, as prevails in the stoma...

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Bibliografske podrobnosti
izdano v:Am J Gastroenterol
Main Authors: Wei, Guoxian, Tian, Na, Valery, Adriana C., Zhong, Yi, Schuppan, Detlef, Helmerhorst, Eva J.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461489/
https://ncbi.nlm.nih.gov/pubmed/25895519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajg.2015.97
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