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Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease

Rothia mucilaginosa, a natural microbial inhabitant of the oral cavity, cleaves gluten (gliadin) proteins at regions that are resistant to degradation by mammalian enzymes. The aim of this study was to investigate to what extent the R. mucilaginosa cell-associated enzymes abolish gliadin immunogenic...

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Detalhes bibliográficos
Main Authors: Tian, Na, Wei, Guoxian, Schuppan, Detlef, Helmerhorst, Eva J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200315/
https://ncbi.nlm.nih.gov/pubmed/25147233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00144.2014
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