Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.

Many heterologously expressed mutants of the cystic fibrosis transmembrane conductance regulator (CFTR) exhibit residual chloride channel activity that can be stimulated by agonists of the adenylate cyclase/protein kinase A pathway. Because of clinical implications for cystic fibrosis of activating...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kelley, T J, Al-Nakkash, L, Cotton, C U, Drumm, M L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755664/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118819
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