Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.

Many heterologously expressed mutants of the cystic fibrosis transmembrane conductance regulator (CFTR) exhibit residual chloride channel activity that can be stimulated by agonists of the adenylate cyclase/protein kinase A pathway. Because of clinical implications for cystic fibrosis of activating...

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Pubblicato in:	J Clin Invest
Autori principali:	Kelley, T J, Al-Nakkash, L, Cotton, C U, Drumm, M L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755664/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118819
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