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Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

Mitochondria were isolated from skin fibroblast cultures derived from healthy individuals (controls) and from a group patients with complex I (NADH-CoQ reductase) deficiency of the mitochondrial respiratory chain. The complex I deficient patients included those with fatal infantile lactic acidosis (...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Pitkanen, S, Robinson, B H
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1996
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507436/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755643/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118798
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