Efficacy of adoptive T cell therapy is improved by treatment with the antioxidant N-acetyl cysteine, which limits activation-induced T cell death

While adoptive transfer of autologous tumor antigen-specific T cell immunotherapy can produce remarkable clinical efficacy, most patients do not achieve durable complete responses. We hypothesized that reducing susceptibility of T cells to activation-induced cell death (AICD), which increases during...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Scheffel, Matthew J., Scurti, Gina, Simms, Patricia, Garrett-Mayer, Elizabeth, Mehrotra, Shikhar, Nishimura, Michael I., Voelkel-Johnson, Christina
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074089/
https://ncbi.nlm.nih.gov/pubmed/27742673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0587
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