N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner

Therapeutic outcomes for adoptive cell transfer (ACT) therapy are constrained by the quality of the infused T cells. The rapid expansion necessary to obtain large numbers of cells results in a more terminally differentiated phenotype with decreased durability and functionality. N-acetyl cysteine (NA...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Scheffel, Matthew J., Scurti, Gina, Wyatt, Megan M., Garrett-Mayer, Elizabeth, Paulos, Chrystal M., Nishimura, Michael I., Voelkel-Johnson, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862784/
https://ncbi.nlm.nih.gov/pubmed/29396710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2120-5
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