Promoting Thiol Expression Increases The Durability of Antitumor T cell Functions

Ex vivo-expanded CD8(+) T cells used for adoptive immunotherapy generally acquire an effector memory-like phenotype (T(EM) cells). With regard to therapeutic applications, two undesired features of this phenotype in vivo are limited persistence and reduced anti-tumor efficacy, relative to CD8(+) T c...

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主要な著者: Kesarwani, Pravin, Al-Khami, Amir A., Scurti, Gina, Thyagarajan, Krishnamurthy, Kaur, Navtej, Husain, Shahid, Fang, Quan, Naga, Osama S., Simms, Patricia, Beeson, Gyda, Voelkel-Johnson, Christina, Garrett-Mayer, Elizabeth, Beeson, Craig C., Nishimura, Michael I., Mehrotra, Shikhar
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216764/
https://ncbi.nlm.nih.gov/pubmed/25164014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1084
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