Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control

Advancements in adoptive cell transfer therapy (ACT) has led to the use of T cells engineered with tumor specific T cell receptors, which after rapid expansion can be obtained in sufficient numbers for treating patients. However, due to massive proliferation these cells are close to replicative sene...

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Udgivet i:Oncotarget
Main Authors: Kesarwani, Pravin, Chakraborty, Paramita, Gudi, Radhika, Chatterjee, Shilpak, Scurti, Gina, Toth, Kyle, Simms, Patt, Husain, Mahvash, Armeson, Kent, Husain, Shahid, Garrett-Mayer, Elizabeth, Vasu, Chethamarakshan, Nishimura, Michael I., Mehrotra, Shikhar
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper: Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342484/
https://ncbi.nlm.nih.gov/pubmed/27750220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12674
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