Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

The pathological hallmark of Alzheimer disease is the accumulation of neurofibrillary tangles and neuritic plaques in the brains of patients. Plaque cores contain a 4- to 5-kDa amyloid beta-protein fragment which is also found in the cerebral blood vessels of affected individuals. Since amyloid depo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Adler, M J, Coronel, C, Shelton, E, Seegmiller, J E, Dewji, N N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1702541/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.1.16
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