Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.
The pathological hallmark of Alzheimer disease is the accumulation of neurofibrillary tangles and neuritic plaques in the brains of patients. Plaque cores contain a 4- to 5-kDa amyloid beta-protein fragment which is also found in the cerebral blood vessels of affected individuals. Since amyloid depo...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1702541/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.1.16 |
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