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Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

Various compounds that affect signal transduction regulate the relative utilization of alternative processing pathways for the beta-amyloid precursor protein (beta APP) in intact cells, increasing the production of nonamyloidogenic soluble beta APP (s beta APP) and decreasing that of amyloidogenic b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Xu, H, Sweeney, D, Greengard, P, Gandy, S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39490/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633020/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4081
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