Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle.

We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-release channels. Imperatoxin inhibitor has a M(r) of approximately 10,500, inhibits [3H]ryanodine bind...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Valdivia, H H, Kirby, M S, Lederer, W J, Coronado, R
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1334561/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.24.12185
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