Phosphorylation of RyR2 Ser‐2814 by CaMKII mediates β1‐adrenergic stress induced Ca2+‐leak from the sarcoplasmic reticulum

Adrenergic stimulation, while being the central mechanism of cardiac positive inotropy, is a universally acknowledged inductor of undesirable sarcoplasmic reticulum (SR) Ca2+ leak. However, the exact mechanisms for this remained unspecified so far. This study shows that Ca2+/calmodulin‐dependent pro...

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Manylion Llyfryddiaeth

Prif Awduron:	Maria J. Baier, Jannis Noack, Mark Tilmann Seitz, Lars S. Maier, Stefan Neef
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2021-10-01
Cyfres:	FEBS Open Bio
Pynciau:	adrenergic stress CaMKII RyR2 Ser‐2814 SR Ca2+ leak
Mynediad Ar-lein:	https://doi.org/10.1002/2211-5463.13274
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!