Separation of Insulin Signaling into Distinct GLUT4 Translocation and Activation Steps

GLUT4 (glucose transporter 4) plays a pivotal role in insulin-induced glucose uptake to maintain normal blood glucose levels. Here, we report that a cell-permeable phosphoinositide-binding peptide induced GLUT4 translocation to the plasma membrane without inhibiting IRAP (insulin-responsive aminopep...

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Bibliographic Details
Main Authors: Funaki, Makoto, Randhawa, Paramjeet, Janmey, Paul A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC507006/
https://ncbi.nlm.nih.gov/pubmed/15314166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7567-7577.2004
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