The Pleckstrin Homology (PH) Domain-Interacting Protein Couples the Insulin Receptor Substrate 1 PH Domain to Insulin Signaling Pathways Leading to Mitogenesis and GLUT4 Translocation

Receptor-mediated tyrosine phosphorylation of the insulin receptor substrate 1 (IRS-1) is required for the propagation of many of insulin's biological effects. The amino-terminal pleckstrin homology (PH) domain of IRS-1 plays a pivotal role in promoting insulin receptor (IR)-IRS-1 protein inter...

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Bibliographische Detailangaben
Hauptverfasser: Farhang-Fallah, Janet, Randhawa, Varinder K., Nimnual, Anjaruwee, Klip, Amira, Bar-Sagi, Dafna, Rozakis-Adcock, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139823/
https://ncbi.nlm.nih.gov/pubmed/12242307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7325-7336.2002
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