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Saccharomyces cerevisiae Srs2 DNA Helicase Selectively Blocks Expansions of Trinucleotide Repeats

Trinucleotide repeats (TNRs) undergo frequent mutations in families afflicted with certain neurodegenerative disorders and in model organisms. TNR instability is modulated both by the repeat tract itself and by cellular proteins. Here we identified the Saccharomyces cerevisiae DNA helicase Srs2 as a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bhattacharyya, Saumitri, Lahue, Robert S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC507003/
https://ncbi.nlm.nih.gov/pubmed/15314145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7324-7330.2004
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