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Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. Hairpins are therefore considered likely intermediates during the expansion pr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2425488/ https://ncbi.nlm.nih.gov/pubmed/18440969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn225 |
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