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Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism
Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise t...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068295/ https://ncbi.nlm.nih.gov/pubmed/27681620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610746113 |
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