Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens

Deletion mutants in the lpxM gene in two Y. pestis strains, the live Russian vaccine strain EV NIIEG and a fully virulent strain, 231, synthesise a less toxic penta-acylated lipopolysaccharide (LPS). Analysis of these mutants revealed they possessed marked reductions in expression and immunoreactivi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Feodorova, V.A., Pan'kina, L.N., Savostina, E.P., Kuznetsov, O.S., Konnov, N.P., Sayapina, L.V., Dentovskaya, S.V., Shaikhutdinova, R.Z., Ageev, S.A., Lindner, B., A.N.Kondakova, Bystrova, O.V., Kocharova, N.A., Senchenkova, S.N., Holst, O., Pier, G.B., Knirel, Y.A., Anisimov, A.P., Motin, V.L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999740/
https://ncbi.nlm.nih.gov/pubmed/19428838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.02.020
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