Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens

Deletion mutants in the lpxM gene in two Y. pestis strains, the live Russian vaccine strain EV NIIEG and a fully virulent strain, 231, synthesise a less toxic penta-acylated lipopolysaccharide (LPS). Analysis of these mutants revealed they possessed marked reductions in expression and immunoreactivi...

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Main Authors: Feodorova, V.A., Pan'kina, L.N., Savostina, E.P., Kuznetsov, O.S., Konnov, N.P., Sayapina, L.V., Dentovskaya, S.V., Shaikhutdinova, R.Z., Ageev, S.A., Lindner, B., A.N.Kondakova, Bystrova, O.V., Kocharova, N.A., Senchenkova, S.N., Holst, O., Pier, G.B., Knirel, Y.A., Anisimov, A.P., Motin, V.L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999740/
https://ncbi.nlm.nih.gov/pubmed/19428838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.02.020
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