A novel regulatory element (E77) isolated from CHO‐K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells

Vectors flanked by regulatory DNA elements have been used to generate stable cell lines with high productivity and transgene stability; however, regulatory elements in Chinese hamster ovary (CHO) cells, which are the most widely used mammalian cells in biopharmaceutical production, are still poorly...

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Bibliografiske detaljer
Udgivet i:Biotechnol J
Main Authors: Kang, Shin‐Young, Kim, Yeon‐Gu, Kang, Seunghee, Lee, Hong Weon, Lee, Eun Gyo
Format: Artigo
Sprog:Inglês
Udgivet: WILEY‐VCH Verlag 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067685/
https://ncbi.nlm.nih.gov/pubmed/26762773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201500464
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