A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary (CHO) Cell Metabolism

Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are widely used in mammalian cell line engineering research. To elucidate metabolic bottlenecks in protein production and to guide cell engineering and bioprocess optimization, we reconstructed the metabolic pathways in...

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Publicado en:Cell Syst
Main Authors: Hefzi, Hooman, Ang, Kok Siong, Hanscho, Michael, Bordbar, Aarash, Ruckerbauer, David, Lakshmanan, Meiyappan, Orellana, Camila A., Baycin-Hizal, Deniz, Huang, Yingxiang, Ley, Daniel, Martinez, Veronica S., Kyriakopoulos, Sarantos, Jiménez, Natalia E., Zielinski, Daniel C., Quek, Lake-Ee, Wulff, Tune, Arnsdorf, Johnny, Li, Shangzhong, Lee, Jae Seong, Paglia, Giuseppe, Loira, Nicolas, Spahn, Philipp N., Pedersen, Lasse E., Gutierrez, Jahir M., King, Zachary A., Lund, Anne Mathilde, Nagarajan, Harish, Thomas, Alex, Abdel-Haleem, Alyaa M., Zanghellini, Juergen, Kildegaard, Helene F., Voldborg, Bjørn G., Gerdtzen, Ziomara P., Betenbaugh, Michael J., Palsson, Bernhard O., Andersen, Mikael R., Nielsen, Lars K., Borth, Nicole, Lee, Dong-Yup, Lewis, Nathan E.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132346/
https://ncbi.nlm.nih.gov/pubmed/27883890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.10.020
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