Novel STIM1-dependent control of Ca(2+) clearance regulates NFAT activity during T-cell activation

Antigen presentation to the T-cell receptor leads to sustained cytosolic Ca(2+) elevation, which is critical for T-cell activation. We previously showed that in activated T cells, Ca(2+) clearance is inhibited by the endoplasmic reticulum Ca(2+) sensor stromal interacting molecule 1 (STIM1) via asso...

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Vydáno v:FASEB J
Hlavní autoři: Samakai, Elsie, Hooper, Robert, Martin, Kayla A., Shmurak, Maya, Zhang, Yi, Kappes, Dietmar J., Tempera, Italo, Soboloff, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067253/
https://ncbi.nlm.nih.gov/pubmed/27528628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600532R
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