Novel STIM1-dependent control of Ca(2+) clearance regulates NFAT activity during T-cell activation

Antigen presentation to the T-cell receptor leads to sustained cytosolic Ca(2+) elevation, which is critical for T-cell activation. We previously showed that in activated T cells, Ca(2+) clearance is inhibited by the endoplasmic reticulum Ca(2+) sensor stromal interacting molecule 1 (STIM1) via asso...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:FASEB J
Main Authors: Samakai, Elsie, Hooper, Robert, Martin, Kayla A., Shmurak, Maya, Zhang, Yi, Kappes, Dietmar J., Tempera, Italo, Soboloff, Jonathan
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067253/
https://ncbi.nlm.nih.gov/pubmed/27528628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600532R
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki