Novel STIM1-dependent control of Ca(2+) clearance regulates NFAT activity during T-cell activation

Antigen presentation to the T-cell receptor leads to sustained cytosolic Ca(2+) elevation, which is critical for T-cell activation. We previously showed that in activated T cells, Ca(2+) clearance is inhibited by the endoplasmic reticulum Ca(2+) sensor stromal interacting molecule 1 (STIM1) via asso...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Samakai, Elsie, Hooper, Robert, Martin, Kayla A., Shmurak, Maya, Zhang, Yi, Kappes, Dietmar J., Tempera, Italo, Soboloff, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067253/
https://ncbi.nlm.nih.gov/pubmed/27528628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600532R
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados