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Ca(2+) export pump PMCA clears near-membrane Ca(2+) to facilitate store-operated Ca(2+) entry and NFAT activation

Ca(2+) signals, which facilitate pluripotent changes in cell fate, reflect the balance between cation entry and export. Overexpression of both isoforms of the Ca(2+) extruding plasma membrane calcium ATPase 4 (PMCA4) pump in Jurkat T cells unexpectedly increased activation of the Ca(2+)-dependent tr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Signal
Prif Awduron: Go, Christina K., Hooper, Robert, Aronson, Matthew R., Schultz, Bryant, Cangoz, Taha, Nemani, Neeharika, Zhang, Yi, Madesh, Muniswamy, Soboloff, Jonathan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800072/
https://ncbi.nlm.nih.gov/pubmed/31594854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw2627
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