Targeting the kinase activities of ATR and ATM exhibits therapeutic potential in a mouse model of MLL-rearranged AML

Among the various subtypes of Acute Myeloid Leukemia (AML), those with chromosomal rearrangements of the MLL oncogene (AML-MLL) have a poor prognosis. AML-MLL tumor cells are resistant to current genotoxic therapies due to an attenuated response by p53, which induces cell cycle arrest and apoptosis...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Morgado-Palacin, Isabel, Day, Amanda, Murga, Matilde, Lafarga, Vanesa, Anton, Marta Elena, Tubbs, Anthony, Chen, Hua Tang, Ergan, Aysegul, Anderson, Rhonda, Bhandoola, Avinash, Pike, Kurt G., Barlaam, Bernard, Cadogan, Elaine, Wang, Xi, Pierce, Andrew J., Hubbard, Chad, Armstrong, Scott A., Nussenzweig, André, Fernandez-Capetillo, Oscar
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066844/
https://ncbi.nlm.nih.gov/pubmed/27625305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad8243
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