Allosteric Regulation of Mammalian Pantothenate Kinase

Pantothenate kinase is the master regulator of CoA biosynthesis and is feedback-inhibited by acetyl-CoA. Comparison of the human PANK3·acetyl-CoA complex to the structures of PANK3 in four catalytically relevant complexes, 5′-adenylyl-β,γ-imidodiphosphate (AMPPNP)·Mg(2+), AMPPNP·Mg(2+)·pantothenate,...

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Foilsithe in:J Biol Chem
Main Authors: Subramanian, Chitra, Yun, Mi-Kyung, Yao, Jiangwei, Sharma, Lalit Kumar, Lee, Richard E., White, Stephen W., Jackowski, Suzanne, Rock, Charles O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064008/
https://ncbi.nlm.nih.gov/pubmed/27555321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748061
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