A therapeutic approach to pantothenate kinase associated neurodegeneration

Pantothenate kinase (PANK) is a metabolic enzyme that regulates cellular coenzyme A (CoA) levels. There are three human PANK genes, and inactivating mutations in PANK2 lead to pantothenate kinase associated neurodegeneration (PKAN). Here we performed a library screen followed by chemical optimizatio...

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Publicado en:Nat Commun
Autores principales: Sharma, Lalit Kumar, Subramanian, Chitra, Yun, Mi-Kyung, Frank, Matthew W., White, Stephen W., Rock, Charles O., Lee, Richard E., Jackowski, Suzanne
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199309/
https://ncbi.nlm.nih.gov/pubmed/30352999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06703-2
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