A Pantothenate Kinase-Deficient Mouse Model Reveals a Gene Expression Program Associated with Brain Coenzyme A Reduction

Pantothenate kinase (PanK) is the first enzyme in the coenzyme A (CoA) biosynthetic pathway. The differential expression of the four-active mammalian PanK isoforms regulates CoA levels in different tissues and PANK2 mutations lead to Pantothenate Kinase Associated Neurodegeneration (PKAN). The molec...

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Bibliografiske detaljer
Udgivet i:Biochim Biophys Acta Mol Basis Dis
Main Authors: Subramanian, Chitra, Yao, Jiangwei, Frank, Matthew W., Rock, Charles O., Jackowski, Suzanne
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078592/
https://ncbi.nlm.nih.gov/pubmed/31918006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2020.165663
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