Post-hoc Analysis for Detecting Individual Rare Variant Risk Associations using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Rare variants have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional single-marker methods for statistical analysis are underpowered for typical sequencing study sample sizes. Multi-marker burden-ty...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:Genet Epidemiol
প্রধান লেখক: Larson, Nicholas B., McDonnell, Shannon, Albright, Lisa Cannon, Teerlink, Craig, Stanford, Janet, Ostrander, Elaine A., Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A., Lange, Ethan, Schleutker, Johanna, Carpten, John D., Powell, Isaac, Bailey-Wilson, Joan, Cussenot, Olivier, Cancel-Tassin, Geraldine, Giles, Graham, MacInnis, Robert, Maier, Christiane, Whittemore, Alice S., Hsieh, Chih-Lin, Wiklund, Fredrik, Catolona, William J., Foulkes, William, Mandal, Diptasri, Eeles, Rosalind, Kote-Jarai, Zsofia, Ackerman, Michael J., Olson, Timothy M., Klein, Christopher J., Thibodeau, Stephen N., Schaid, Daniel J.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: 2016
বিষয়গুলি:
Article
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063501/
https://ncbi.nlm.nih.gov/pubmed/27312771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21983
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