Post-hoc Analysis for Detecting Individual Rare Variant Risk Associations using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Rare variants have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional single-marker methods for statistical analysis are underpowered for typical sequencing study sample sizes. Multi-marker burden-ty...

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Bibliografski detalji
Izdano u:Genet Epidemiol
Glavni autori: Larson, Nicholas B., McDonnell, Shannon, Albright, Lisa Cannon, Teerlink, Craig, Stanford, Janet, Ostrander, Elaine A., Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A., Lange, Ethan, Schleutker, Johanna, Carpten, John D., Powell, Isaac, Bailey-Wilson, Joan, Cussenot, Olivier, Cancel-Tassin, Geraldine, Giles, Graham, MacInnis, Robert, Maier, Christiane, Whittemore, Alice S., Hsieh, Chih-Lin, Wiklund, Fredrik, Catolona, William J., Foulkes, William, Mandal, Diptasri, Eeles, Rosalind, Kote-Jarai, Zsofia, Ackerman, Michael J., Olson, Timothy M., Klein, Christopher J., Thibodeau, Stephen N., Schaid, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063501/
https://ncbi.nlm.nih.gov/pubmed/27312771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21983
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