Post-hoc Analysis for Detecting Individual Rare Variant Risk Associations using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Rare variants have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional single-marker methods for statistical analysis are underpowered for typical sequencing study sample sizes. Multi-marker burden-ty...

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Publicado no:Genet Epidemiol
Main Authors: Larson, Nicholas B., McDonnell, Shannon, Albright, Lisa Cannon, Teerlink, Craig, Stanford, Janet, Ostrander, Elaine A., Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A., Lange, Ethan, Schleutker, Johanna, Carpten, John D., Powell, Isaac, Bailey-Wilson, Joan, Cussenot, Olivier, Cancel-Tassin, Geraldine, Giles, Graham, MacInnis, Robert, Maier, Christiane, Whittemore, Alice S., Hsieh, Chih-Lin, Wiklund, Fredrik, Catolona, William J., Foulkes, William, Mandal, Diptasri, Eeles, Rosalind, Kote-Jarai, Zsofia, Ackerman, Michael J., Olson, Timothy M., Klein, Christopher J., Thibodeau, Stephen N., Schaid, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063501/
https://ncbi.nlm.nih.gov/pubmed/27312771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21983
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