gsSKAT: Rapid Gene-Set Analysis and Multiple Testing Correction for Rare-variant Association Studies using Weighted Linear Kernels

Next-generation sequencing technologies have afforded unprecedented characterization of low-frequency and rare genetic variation. Due to low power for single-variant testing, aggregative methods are commonly used to combine observed rare variation within a single gene. Causal variation may also aggr...

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Publicado en:Genet Epidemiol
Autores principales: Larson, Nicholas B., McDonnell, Shannon, Albright, Lisa Cannon, Teerlink, Craig, Stanford, Janet, Ostrander, Elaine A., Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A., Lange, Ethan, Schleutker, Johanna, Carpten, John D., Powell, Isaac, Bailey-Wilson, Joan E., Cussenot, Olivier, Cancel-Tassin, Geraldine, Giles, Graham G., MacInnis, Robert J., Maier, Christiane, Whittemore, Alice S., Hsieh, Chih-Lin, Wiklund, Fredrik, Catolona, William J., Foulkes, William, Mandal, Diptasri, Eeles, Rosalind, Kote-Jarai, Zsofia, Ackerman, Michael J., Olson, Timothy M., Klein, Christopher J., Thibodeau, Stephen N., Schaid, Daniel J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397327/
https://ncbi.nlm.nih.gov/pubmed/28211093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22036
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