gsSKAT: Rapid Gene-Set Analysis and Multiple Testing Correction for Rare-variant Association Studies using Weighted Linear Kernels

Next-generation sequencing technologies have afforded unprecedented characterization of low-frequency and rare genetic variation. Due to low power for single-variant testing, aggregative methods are commonly used to combine observed rare variation within a single gene. Causal variation may also aggr...

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Detalhes bibliográficos
Publicado no:Genet Epidemiol
Main Authors: Larson, Nicholas B., McDonnell, Shannon, Albright, Lisa Cannon, Teerlink, Craig, Stanford, Janet, Ostrander, Elaine A., Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A., Lange, Ethan, Schleutker, Johanna, Carpten, John D., Powell, Isaac, Bailey-Wilson, Joan E., Cussenot, Olivier, Cancel-Tassin, Geraldine, Giles, Graham G., MacInnis, Robert J., Maier, Christiane, Whittemore, Alice S., Hsieh, Chih-Lin, Wiklund, Fredrik, Catolona, William J., Foulkes, William, Mandal, Diptasri, Eeles, Rosalind, Kote-Jarai, Zsofia, Ackerman, Michael J., Olson, Timothy M., Klein, Christopher J., Thibodeau, Stephen N., Schaid, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397327/
https://ncbi.nlm.nih.gov/pubmed/28211093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22036
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