Synthesis and pharmacological evaluation of indole derivatives as deaza analogues of potent human neutrophil elastase inhibitors (HNE)

A number of N-benzoylindoles were designed and synthesized as deaza analogues of our previously reported potent and selective HNE inhibitors with an indazole scaffold. The new compounds containing substituents and functions that were most active in the previous series were active in the micromolar r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Dev Res
Prif Awduron: Crocetti, Letizia, Schepetkin, Igor A., Ciciani, Giovanna, Giovannoni, Maria Paola, Guerrini, Gabriella, Iacovone, Antonella, Khlebnikov, Andrei I., Kirpotina, Liliya N., Quinn, Mark T., Vergelli, Claudia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062748/
https://ncbi.nlm.nih.gov/pubmed/27474878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ddr.21323
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg