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New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation

The macrolide rapamycin and its analogues (rapalogs) constitute the first generation of mammalian target of rapamycin (mTOR) inhibitors. Since the introduction of rapamycin as an immunosuppressant, there has been extensive progress in understanding its complex mechanisms of action. New insights into...

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Détails bibliographiques
Publié dans:Br J Clin Pharmacol
Auteurs principaux: Waldner, Matthias, Fantus, Daniel, Solari, Mario, Thomson, Angus W.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061789/
https://ncbi.nlm.nih.gov/pubmed/26810941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12893
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