Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The development of selective and potent BET (bromo and extra-terminal) inhibitors and their significant activity in diverse tumor models have rapidly translated into clinical studies and have motivated drug development effort...

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Vydáno v:Sci Adv
Hlavní autoři: Picaud, Sarah, Leonards, Katharina, Lambert, Jean-Philippe, Dovey, Oliver, Wells, Christopher, Fedorov, Oleg, Monteiro, Octovia, Fujisawa, Takao, Wang, Chen-Yi, Lingard, Hannah, Tallant, Cynthia, Nikbin, Nikzad, Guetzoyan, Lucie, Ingham, Richard, Ley, Steven V., Brennan, Paul, Muller, Susanne, Samsonova, Anastasia, Gingras, Anne-Claude, Schwaller, Juerg, Vassiliou, George, Knapp, Stefan, Filippakopoulos, Panagis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061470/
https://ncbi.nlm.nih.gov/pubmed/27757418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600760
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