iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

Adipose-resident invariant natural killer T (iNKT) cells are key players in metabolic regulation. iNKT cells are innate lipid sensors, and their activation, using their prototypic ligand α-galactosylceramide (αGalCer), induces weight loss and restores glycemic control in obesity. Here, iNKT activati...

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Publicado en:Cell Metab
Autores principales: Lynch, Lydia, Hogan, Andrew E., Duquette, Danielle, Lester, Chantel, Banks, Alexander, LeClair, Katherine, Cohen, David E., Ghosh, Abhisek, Lu, Bing, Corrigan, Michelle, Stevanovic, Darko, Maratos-Flier, Eleftheria, Drucker, Daniel J., O’Shea, Donal, Brenner, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061124/
https://ncbi.nlm.nih.gov/pubmed/27593966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.08.003
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