A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains

BACKGROUND: High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses of antigen specificity, clonality and diversity of T lymphocytes. Here, we developed a new TCR repertoire analysis method using 454 DNA sequencing technology in combination with an adaptor-ligation...

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Vydáno v:BMC Immunol
Hlavní autoři: Kitaura, Kazutaka, Shini, Tadasu, Matsutani, Takaji, Suzuki, Ryuji
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059964/
https://ncbi.nlm.nih.gov/pubmed/27729009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-016-0177-5
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