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Phospha-Michael Addition as a New Click Reaction for Protein Functionalization
A new type of click reaction between alkyl phosphine and acrylamide was developed and applied for site-specific protein labeling in vitro and on live cells. Acrylamide is a small electrophilic olefin that readily undergoes phospha-Michael addition with alkyl phosphine. Our kinetic study indicated a...
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| Published in: | Chembiochem |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5059841/ https://ncbi.nlm.nih.gov/pubmed/26756316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500697 |
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