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Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow

The development of a ‘click, click, cy-click’ process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a m...

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書誌詳細
主要な著者: Zang, Qin, Javed, Salim, Ullah, Farman, Zhou, Aihua, Knudtson, Christopher A., Bi, Danse, Basha, Fatima Z., Organ, Michael G., Hanson, Paul R.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171749/
https://ncbi.nlm.nih.gov/pubmed/21927510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0030-1260112
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