Synthesis of a Unique Isoindoline/Tetrahydroisoquinoline-based Tricyclic Sultam Library Utilizing a Heck-aza-Michael Strategy

The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and int...

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Detalhes bibliográficos
Main Authors: Zang, Qin, Javed, Salim, Porubsky, Patrick, Ullah, Farman, Neuenswander, Benjamin, Lushington, Gerald H., Basha, Fatima Z., Organ, Michael G., Hanson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341135/
https://ncbi.nlm.nih.gov/pubmed/22311745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co200181x
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