Two Rapid Catalyst-Free Click Reactions for In Vivo Protein Labeling of Genetically Encoded Strained Alkene/Alkyne Functionalities

[Image: see text] Detailed kinetic analyses of inverse electron-demand Diels–Alder cycloaddition and nitrilimine-alkene/alkyne 1,3-diploar cycloaddition reactions were conducted and the reactions were applied for rapid protein bioconjugation. When reacted with a tetrazine or a diaryl nitrilimine, st...

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Auteurs principaux: Kurra, Yadagiri, Odoi, Keturah A., Lee, Yan-Jiun, Yang, Yanyan, Lu, Tongxiang, Wheeler, Steven E., Torres-Kolbus, Jessica, Deiters, Alexander, Liu, Wenshe R.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166034/
https://ncbi.nlm.nih.gov/pubmed/25158039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500361d
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