Bimodal antagonism of PKA signalling by ARHGAP36

Protein kinase A is a key mediator of cAMP signalling downstream of G-protein-coupled receptors, a signalling pathway conserved in all eukaryotes. cAMP binding to the regulatory subunits (PKAR) relieves their inhibition of the catalytic subunits (PKAC). Here we report that ARHGAP36 combines two dist...

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Publicat a:Nat Commun
Autors principals: Eccles, Rebecca L., Czajkowski, Maciej T., Barth, Carolin, Müller, Paul Markus, McShane, Erik, Grunwald, Stephan, Beaudette, Patrick, Mecklenburg, Nora, Volkmer, Rudolf, Zühlke, Kerstin, Dittmar, Gunnar, Selbach, Matthias, Hammes, Annette, Daumke, Oliver, Klussmann, Enno, Urbé, Sylvie, Rocks, Oliver
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059767/
https://ncbi.nlm.nih.gov/pubmed/27713425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12963
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