Bimodal antagonism of PKA signalling by ARHGAP36

Protein kinase A is a key mediator of cAMP signalling downstream of G-protein-coupled receptors, a signalling pathway conserved in all eukaryotes. cAMP binding to the regulatory subunits (PKAR) relieves their inhibition of the catalytic subunits (PKAC). Here we report that ARHGAP36 combines two dist...

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Publicado no:Nat Commun
Main Authors: Eccles, Rebecca L., Czajkowski, Maciej T., Barth, Carolin, Müller, Paul Markus, McShane, Erik, Grunwald, Stephan, Beaudette, Patrick, Mecklenburg, Nora, Volkmer, Rudolf, Zühlke, Kerstin, Dittmar, Gunnar, Selbach, Matthias, Hammes, Annette, Daumke, Oliver, Klussmann, Enno, Urbé, Sylvie, Rocks, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059767/
https://ncbi.nlm.nih.gov/pubmed/27713425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12963
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