Smad4 is required to inhibit osteoclastogenesis and maintain bone mass

Bone homeostasis is maintained as a delicate balance between bone-resorption and bone-formation, which are coupled to maintain appropriate bone mass. A critical question is how bone-resorption is terminated to allow bone-formation to occur. Here, we show that TGFβs inhibit osteoclastogenesis and mai...

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Publicat a:Sci Rep
Autors principals: Morita, Mayu, Yoshida, Shigeyuki, Iwasaki, Ryotaro, Yasui, Tetsuro, Sato, Yuiko, Kobayashi, Tami, Watanabe, Ryuichi, Oike, Takatsugu, Miyamoto, Kana, Takami, Masamichi, Ozato, Keiko, Deng, Chu-Xia, Aburatani, Hiroyuki, Tanaka, Sakae, Yoshimura, Akihiko, Toyama, Yoshiaki, Matsumoto, Morio, Nakamura, Masaya, Kawana, Hiromasa, Nakagawa, Taneaki, Miyamoto, Takeshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059689/
https://ncbi.nlm.nih.gov/pubmed/27731422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35221
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