Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has provided unprecedented results in cancer treatment in the recent years. Development of chemical inhibitors for this pathway lags the antibody development because of insufficient structural information. The first nonpeptid...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Zak, Krzysztof M., Grudnik, Przemyslaw, Guzik, Katarzyna, Zieba, Bartosz J., Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058683/
https://ncbi.nlm.nih.gov/pubmed/27083005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8730
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items