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Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole

This study evaluated the effects of cytochrome P450 (CYP) 2C19 polymorphisms on tacrolimus pharmacokinetics when coadministered with voriconazole. Eighteen healthy volunteers, including 6 individuals in each CYP2C19 genotype (extensive metabolizers [EMs], intermediate metabolizers [IMs], and poor me...

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Détails bibliographiques
Publié dans:J Clin Pharmacol
Auteurs principaux: Imamura, Chiyo K., Furihata, Kenichi, Okamoto, Shinichiro, Tanigawara, Yusuke
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057355/
https://ncbi.nlm.nih.gov/pubmed/26239045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.605
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