The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients

Tacrolimus (Tac) is an effective remission inducer of refractory ulcerative colitis (UC). Gene polymorphisms result in interindividual variability in Tac pharmacokinetics. In this study, we aimed to examine the relationships between gene polymorphisms and the metabolism, pharmacokinetics, and therap...

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Publicado en:PLoS One
Autores principales: Furuse, Maizumi, Hosomi, Shuhei, Nishida, Yu, Itani, Shigehiro, Nadatani, Yuji, Fukunaga, Shusei, Otani, Koji, Tanaka, Fumio, Nagami, Yasuaki, Taira, Koichi, Kamata, Noriko, Watanabe, Toshio, Watanabe, Kenji, Fujiwara, Yasuhiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062093/
https://ncbi.nlm.nih.gov/pubmed/33886687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250597
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