The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients

Tacrolimus (Tac) is an effective remission inducer of refractory ulcerative colitis (UC). Gene polymorphisms result in interindividual variability in Tac pharmacokinetics. In this study, we aimed to examine the relationships between gene polymorphisms and the metabolism, pharmacokinetics, and therap...

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Publicat a:PLoS One
Autors principals: Furuse, Maizumi, Hosomi, Shuhei, Nishida, Yu, Itani, Shigehiro, Nadatani, Yuji, Fukunaga, Shusei, Otani, Koji, Tanaka, Fumio, Nagami, Yasuaki, Taira, Koichi, Kamata, Noriko, Watanabe, Toshio, Watanabe, Kenji, Fujiwara, Yasuhiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062093/
https://ncbi.nlm.nih.gov/pubmed/33886687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250597
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