The impact of cytochrome P450 3A genetic polymorphisms on tacrolimus pharmacokinetics in ulcerative colitis patients

Tacrolimus (Tac) is an effective remission inducer of refractory ulcerative colitis (UC). Gene polymorphisms result in interindividual variability in Tac pharmacokinetics. In this study, we aimed to examine the relationships between gene polymorphisms and the metabolism, pharmacokinetics, and therap...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Furuse, Maizumi, Hosomi, Shuhei, Nishida, Yu, Itani, Shigehiro, Nadatani, Yuji, Fukunaga, Shusei, Otani, Koji, Tanaka, Fumio, Nagami, Yasuaki, Taira, Koichi, Kamata, Noriko, Watanabe, Toshio, Watanabe, Kenji, Fujiwara, Yasuhiro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2021
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062093/
https://ncbi.nlm.nih.gov/pubmed/33886687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250597
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